Katherine N. Maloney

Katherine N. Maloney

  • Assistant Professor of Chemistry
  • Phone: 619.849.3425

Education

  • B.S., Chemistry, Pacific Lutheran University
  • Ph.D., Organic Chemistry, Cornell University
  • Cancer Therapeutic Training Postdoctoral Fellowship

Background

Education:

2006-2009

Cancer Therapeutics Training Postdoctoral Fellowship, Scripps Institution of Oceanography/UCSD (with Dr. William Fenical)
 

2000-2006

Ph.D. in Chemistry and Chemical Biology, Cornell University (with Dr. Jon Clardy)

 

1996-2000

B.S. in Chemistry, summa cum laude, Pacific Lutheran University (with Dr. Duane Swank)

Dissertation:

 

Biologically active natural products from plants and their endophytes

Employment:

2012-present

Assistant Professor, Department of Chemistry, Point Loma Nazarene University

 

2009-2012

Assistant Professor, Department of Chemistry, Harvey Mudd College

MEMBERSHIP:
 

American Chemical Society

 
 

American Chemical Society (Division of Organic Chemistry Executive Committee)

 
 

Council on Undergraduate Research

 

Honors and Fellowships

 

Cancer Therapeutics Training Fellowship, UCSD Moores Cancer Center

2007-2009

Certificate of Distinction in Teaching, Harvard University

2006, 2005

American Chemical Society Travel Award

2005

American Society of Pharmacognosy Lynn Brady Travel Award

2005

NSF Graduate Research Fellowship

2001-2004

Herman & Margaret Sokol Fellowship

2001

Cornell University Graduate Fellowship

2000-2001

American Institute of Chemists Award (top chemistry senior)

2000

NSF REU Fellowship, University of Washington

1999

Barry Goldwater Scholarship

1998-2000

Olsen Fellowship for Undergraduate Research, PLU Department of Chemistry

1997-1998

Robert C. Byrd Scholarship

1996-2000

PLU Academic Scholarship

 

1996-2000

Research

Research in the Maloney lab focuses on the small organic molecules (natural products) produced by some organisms to facilitate their interactions with other organisms. In one project, we are growing plant-associated fungi on a variety of different media and characterizing the antibiotic natural products that are selectively produced in some media but not others. In another project, we are exploring the use of natural product profiles to complement molecular (DNA) phylogenetic analyses in studies of the evolutionary relationships among soft corals.

Publications

  1. Murphy, B. T.; Maloney, K. N.; Fenical, W. Marine Microorganisms. In Natural Products: Phytochemistry and Pharmacognosy. Pezzuto, J., Ed.; EOLSS Publishers Co. Ltd.: Oxford, In Press.
  2. Sun,P.; Maloney, K. N.; Nam, S.-J.; Haste, N. M.; Raju, R.; Aalbersberg, W.; Jensen, P. R.; Nizet, V.; Hensler, M. E.; Fenical, W. “Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.” Bioorg. Med. Chem. 2011 19 (22), 6557-6562.
  3. Udwary, D. W.; Gontang, E. A.; Jones, A. C.; Schultz, A. W.; Sorrels, C. M.; Winter, J. M.; Yang, J. Y.; Beauchemind, N.; Capson, T. L.; Clark, B. R.; Esquenazi, E.; Eustáquio, A. S.; Freel, K.; Gonzalez, D. J.; Gerwick, L; Gerwick, W. H.;  Liu, W.-T.; Malloy, K. L.; Maloney, K. N.; Nett, M.; Nunnery, J. K.; Penn, K.; Prieto-Davo, A.; Simmons, T. L.; Weitz, S.; Wilson, M. C.; Tisad, L. S.; Dorrestein, P. C.; Moore, B. S. “Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses.” Appl. Environ. Microb. 2011 77 (11), 3617-3625.
  4. Choi,Y.; Jermihov, K.; Nam, S.; Sturdy, M.; Maloney, K. ; Qiu, X.; Main, M.; Mesecar, A. D.; Pauli, G. F.; Fenical, W. Pezzuto, J. M.; van Breemen, R. R. “Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.” Anal. Chem. 2011 83 (3), 1048-1052.
  5. Haste, N. M.; Perera, V.; Maloney, K. N.; Tran, D. N.; Jensen, P. R.; Fenical, W.; Nizet, V.; Hensler, M. E. “Reappraisal of the natural product antibiotic Etamycin for activity against methicillin-resistant Staphylococcus aureus.” J. Antibiot. 2010 63 (5), 219-224.
  6. Maloney, K. N.; MacMillan, J. B.; Kauffman, C. A.; Jensen, P. R.; DiPasquale, A. G.; Rheingold, A. L.; Fenical, W. “Lodopyridone, a structurally-unprecedented alkaloid from a marine actinomycete.” Org. Lett. 2009 11 (23), 5422-5424.
  7. Maloney, K. N.; Fujita, M.; Eggert., U. S.; Schroeder, F. C.; Field, C. M.; Mitchison, T. J.; Clardy J. “Actin-aggregating cucurbitacins from Physocarpus capitatus.” J. Nat. Prod. 2008 71(11), 1927-1929.
  8. Maloney, K. N.; Hao, W.; Xu, J.; Gibbons, J.; Hucul, J.; Roll, D.; Brady, S. F.; Schroeder, F. C.; Clardy, J. “Phaeosphaeride A, a selective inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.” Org. Lett. 2006 8 (18), 4067-4070.
  9. Smith, P. L.; Maloney, K. N.; Pothen, R. G.; Clardy, J.; Clapham, D. E. “Bisandrographolide from Andrographis paniculata activates TRPV4 channels.” J. Biol. Chem. 2006 281 (40), 29897-29904.
  10. Hieronymus, H.; Lamb, J.; Ross, K. N.; Clement, C.; Peng, X. P.; Rodina, A.; Nieto, M.; Du, J.; Stegmaier, K.; Raj, S. M.; Maloney, K. N.; Clardy, J.; Hahn, W. C.; Chiosis, G.; Golub T. R. “Gene expression signature-based chemical genomic prediction identifies novel class of HSP90 pathway modulators.” Cancer Cell 2006 10 (4), 321-330.
  11. Maloney, K. N. “Book Review: Natural Products Isolation, Second Edition. Satyajit D. Sarker, Zahid Latif, and Alexander I. Gray, Editors. Humana Press.” Chemical Educator 2006 11 (2), 146-147.