Matthieu Rouffet
Matthieu Rouffet
- Assistant Professor
- Phone: 619.849.3278
Education
- Ph.D., Medicinal Chemistry, School of Pharmacy of Reims, France
- M.S., Organic Chemistry, University of Reims, France
- B.S., Chemistry, University of Reims, France
Background
Education:
| 2008 | Ph.D., Medicinal Chemistry, School of Pharmacy of Reims, France |
| 2005 | M.S., Organic Chemistry, University of Reims, France |
| 2000-2004 | B.S., Chemistry, University of Reims, France |
Dissertation:
|
| Synthesis, biological evaluation and determination of the mode of binding of sulfonylhydrazides as MMP inhibitors |
Experience:
| 2009-2011 | Post-Doctoral Associate, University of California, San Diego, California |
| 2005-2008 | Graduate Researcher, School of Pharmacy, Reims, France |
| 2004 | Undergraduate Researcher, University of York, UK |
Publications
- Rouffet, M. and Cohen, S. M., “Emerging trends in metalloprotein inhibition”, Dalton Trans., 2011, 40, 3445.
- Martin, D. P.; Rouffet, M.; and Cohen, S. M., “Illuminating Metal Ion sensors- Benzimidazolesulfonamide metal complexes”, Inorg. Chem., 2010, 49, 22, 10226–10228
- Rouffet, M.; De Oliveira, C. A. F.; Udi, Y.; Agrawal A.; Sagi, I.; McCammon, J. A. and Cohen, S.M., “From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases”, J. Am. Chem. Soc., 2010, 132, 8232–8233
- Rouffet, M. ; Denhez, C.; Bourguet, E.; Bohr, F. and Guillaume, D., “In silico study of MMP inhibition”, Org. Biomol. Res., 2009, 7, 18, 3817-3825
- LeDour, G.; Moroy, G.; Rouffet, M.; Bourguet. E.; Guillaume, D.; Decarme, M.; ElMourabit, H.; Augé, F.; Alix, A.J.P.; Laronze, J.Y.; Bellon, G.; Hornebeck, W. and Sapi, J., “Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity”, Bioorg. Med. Chem., 2008, 16, 8745–8759
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